Dr. Nicholas J. Kenney
Position:
Associate Professor of Biology
Bio:
Dr. Kenney has been in the field of Mammary Stem Cell Biology and Cancer for over two decades. He formally began his Pre-doctoral training at the National Cancer Institute’s Mammary Biology and Tumorigenesis Laboratory and later at the Lombardi Cancer Center, Georgetown University, Washington DC. His research goal is to examine embryonic stem cell specific genes in developing mammary tissue, transplanted mammary tissue, and transgenic animal model systems to better understand the pathobiology of breast cancer. He has served as scientific consultants for the Experimental Biology Group-Biogen/Idec Biosciences, Cambridge, MA, Glaxo/SmithKline Pharmaceutical CO, Riexenart, Belgium and the USAMRMC/CDMRP Breast Cancer Research Program since 1998. Dr. Kenney serves as research faculty in two Howard Hughes Medical Institute Undergraduate Research Programs within the Hampton Roads Consortium. He is also CoPI on a DoD CDMRP Sponsored Undergraduate Summer Program in Prostate Cancer Research (see link-. http://science.beta.hamptonu.edu/prehealth/huucrp.cfm)
Bibliography (selected publications)
Kenney, N.J., Smith, G.H., Rosenberg, K., Cutler, ML., and Dickson, R.B.. (1996). Induction of ductal morphogenesis and lobular hyperplasia by amphiregulin in the mouse mammary gland. Cell Growth and Differentiation 7:1769-1781
Kenney N.J, Smith, G.H., Lawrence, E., Barrett, J.C., and Salomon, D.S. (2001). Identification of stem cell units in mouse mammary gland terminal end buds and ducts. J. of Biomed and Biotech 1:133-143.
Bianco, C., Adkins, H.B., Wechselberger, C., Seno, M., Normanno, N., De Luca, A., Sun, Y., Khan, N., Kenney, N. J., Williams, K., Sanicola, M., and Salomon, D.S. (2002). Cripto-1 activates Nodal and Alk4 dependent and independent signaling pathways in mammary epithelial cells. J Mol. Cell Bio 8:2586-2597
Kenney, N., Korach, K., Bowman, A., Barrett, J.C., and Salomon, D.S. (2003). Effect of Exogenous Epidermal Like Growth Factors on Mammary Gland Development and Differentiation in the Estrogen Receptor-alpha Knockout (ERKO) Mouse. Breast Cancer Res and Treamentt 79:161-173.
Johnson, M., Kenney, N. J., Stoica, A., Hilakivi-Clarke, L., Singh, B., Chepko, G., Clarke, R., Sholler, P., Lirio, A., Foss, C., Reiter, R., Trock, B., Paik, S., and Martin, MB. (2003). Cadmium mimics in vivo the effects of estrogen in vivo in the uterus and mammary gland. Nature Medicine 9:1081-1084.
Kenney NJ, Adkins HB, Sanicola M (2004). Nodal and Cripto-1: embryonic pattern formation genes involved in mammary gland development and tumorigenesis. J Mammary Gland Biol Neoplasia. 9:133-44.
Sun Y, Lowther W, Kato K, Bianco C, Kenney N, Strizzi L, Raafat D, Hirota M, Khan NI, Bargo S, Jones B, Salomon D, Callahan R. (2005) Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling. Oncogene. 34:5365-74.
Cardiff, R. D., and Kenney, N.J. (2007). Mouse Mammary Tumor Biology: A Short History. Advances in Cancer Research. 98:53-116.
Wang W, Morrison B, Galbaugh T, Jose CC, Kenney N, Cutler ML. (2008) Glucocorticoid induced expression of connective tissue growth factor contributes to lactogenic differentiation of mouse mammary epithelial cells. J Cell Physiol. 214:38-46
Wang W, Jose C, Kenney N, Morrison B, Cutler ML. (2009). Global expression profiling reveals regulation of CTGF/CCN2 during lactogenic differentiation. J Cell Commun Signal. 3:43-55
Cardiff RD, Kenney N. (2010) A Compendium of the Mouse Mammary Tumor Biologist: From the Initial Observations in the House Mouse to the Development of Genetically Engineered Mice. Cold Spring Harb Perspect Biol. Oct 20 PMID: 20961975
Educational Background:
Ph.D. (Microbiology),
Howard University, 1993
Classes Taught:
Comparative Anatomy
Research Interests:
Ph.D., 1993; Howard University. Embryonic pattern formation genes involved in mammary gland development and tumorigenesis.
Email:
nicholas.kenney@hamptonu.edu